The biological basis of ageing: a brief guide
DOI:
https://doi.org/10.21504/sajg.v2i2.26Abstract
Improved understanding of genetics and the protective mechanisms that have evolved at the cellular level now makes it possible to present a unified hypothesis of the biology of ageing. Previously, two opposing theories of ageing - "genetic-programming" theory and "wear-and-tear" theory - led to apparently divergent research thrusts. The recognition that both theories are aspects of the same phenomenon different levels of cell function - allows a deeper understanding of the contribution that each school has made to present notions of the biology of ageing.References
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Casarret, G.W. 1959. Similarities and contrasts between radiation and time pathology. Advanced Gerontological Research, 1: 109-63.
Hayflick, L. 1974. The longevity of cultural human cells. American Journal of the Geriatric Society, 22:1-12.
Hayflick, L. & Moorhead, P.S. 1961. Experimental Cellular Research, 25:585-621.
Johnson, T.E. 1988. Mini review: genetic specification of life-span: processes, problems and potentials. Journal of Gerontology, 43:887-92.
Johnson, T.E. & Lithgow, G.J. 1992. The search for the genetic basis of ageing: the identification of gerontogenes in the nematode Caenorhabditis elegans. American Journal of the Geriatric Society, 40:936-45.
Kirkwood, T.B.L. 1977. Evolution and ageing. Nature, 270:301-304.
Martin, G., Sprague, C. & Epstein, C. 1970. Replicative life-span of cultivated human cells: effects of donors' age. Laboratory Investigations, 23:86-92.
Medawar, P.B. 1952. An unsolved problem in biology. London: H.K. Lewis.
Meier, D.E. 1984. The cell biology of ageing: ln: Cassel, C.K. & Walsh, J.R. (Eds) Geriatric medicine. Volume 1. New York: Springer-Verlag.
Morley, J.E. 1992. The resurgence of free radicals. (Editorial.) American Journal of the Geriatric Society, 12: 1285-87.
Rose, M.R. 1984. Laboratory evolution of postponed senescence in Drosophilia melanogaster. Evolution, 38:1004-10.
Rusting, R.L. 1992. Why do we age? Scientific American, 267:86-95.
Williams, G.C. 1957. Pleiotropy, natural selection and the evolution of senescence. Evolution, 11:389-411.
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1993-10-01
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